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Neurons and Oligodendrocytes Recycle Sphingosine 1-Phosphate to Ceramide: SIGNIFICANCE FOR APOPTOSIS AND MULTIPLE SCLEROSIS

Both cultured neonatal rat hippocampal neurons and differentiated oligodendrocytes rapidly metabolized exogenous C(2)- and C(6)-ceramides to sphingosine (Sph) and sphingosine 1-phosphate (S1P) but only minimally to C(16–24)-ceramides. Dihydrosphinolipids were unaffected but were increased by exogeno...

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Autors principals: Qin, Jingdong, Berdyshev, Evgeny, Goya, Jonathan, Natarajan, Viswanathan, Dawson, Glyn
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863199/
https://ncbi.nlm.nih.gov/pubmed/20215115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.076810
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