Mutations of the Opsin Gene (Y102H and I307N) Lead to Light-induced Degeneration of Photoreceptors and Constitutive Activation of Phototransduction in Mice

Mutations in the Rhodopsin (Rho) gene can lead to autosomal dominant retinitis pigmentosa (RP) in humans. Transgenic mouse models with mutations in Rho have been developed to study the disease. However, it is difficult to know the source of the photoreceptor (PR) degeneration in these transgenic mod...

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Autors principals: Budzynski, Ewa, Gross, Alecia K., McAlear, Suzanne D., Peachey, Neal S., Shukla, Meera, He, Feng, Edwards, Malia, Won, Jungyeon, Hicks, Wanda L., Wensel, Theodore G., Naggert, Jurgen K., Nishina, Patsy M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863193/
https://ncbi.nlm.nih.gov/pubmed/20207741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.112409
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