cAMP/CREB-mediated Transcriptional Regulation of Ectonucleoside Triphosphate Diphosphohydrolase 1 (CD39) Expression

CD39 is a transmembrane enzyme that inhibits platelet reactivity and inflammation by phosphohydrolyzing ATP and ADP to AMP. Cyclic AMP (cAMP), an essential second messenger, is particularly important in regulating genes controlling vascular homeostasis. These experiments test the hypothesis that cAM...

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Main Authors: Liao, Hui, Hyman, Matthew C., Baek, Amy E., Fukase, Keigo, Pinsky, David J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Gene Regulation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863166/
https://ncbi.nlm.nih.gov/pubmed/20178980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.116905
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