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F104S c-Mpl responds to a transmembrane domain-binding thrombopoietin receptor agonist: Proof of concept that selected receptor mutations in congenital amegakaryocytic thrombocytopenia can be stimulated with alternative thrombopoietic agents
OBJECTIVE: To determine whether specific c-Mpl mutations might respond to thrombopoietin receptor agonists. METHODS: We created cell line models of type II c-Mpl mutations identified in CAMT. We selected F104S c-Mpl for further study because it exhibited surface expression of the receptor. We measur...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2862996/ https://ncbi.nlm.nih.gov/pubmed/20188141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2010.02.007 |
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