Specific down regulation of 3T3-L1 adipocyte differentiation by cell-permeable antisense HIF1α-oligonucleotide

Hypoxia is a strong modulator of angiogenesis, accelerating adipose tissue expansion, suggesting that hypoxia inducible factor 1α (HIF1α) can be a novel target for anti-obesity. We conjugated antisense-HIF1α-oligonucleotide (ASO) with low molecular weight protamine (LMWP), a cell-penetrating peptide...

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Autors principals: Park, Yoon Shin, Huang, Yongzhuo, Park, Yoon Jeong, David, Allan E., White, Lindsay, He, Huining, Chung, Hee Sun, Yang, Victor C.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862791/
https://ncbi.nlm.nih.gov/pubmed/20109509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2010.01.026
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