Jnk2 Effects on Tumor Development, Genetic Instability and Replicative Stress in an Oncogene-Driven Mouse Mammary Tumor Model

Oncogenes induce cell proliferation leading to replicative stress, DNA damage and genomic instability. A wide variety of cellular stresses activate c-Jun N-terminal kinase (JNK) proteins, but few studies have directly addressed the roles of JNK isoforms in tumor development. Herein, we show that jnk...

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Detalhes bibliográficos
Main Authors: Chen, Peila, O'Neal, Jamye F., Ebelt, Nancy D., Cantrell, Michael A., Mitra, Shreya, Nasrazadani, Azadeh, Vandenbroek, Tracy L., Heasley, Lynn E., Van Den Berg, Carla L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862739/
https://ncbi.nlm.nih.gov/pubmed/20454618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010443
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