Analysis of Gene Expression in PTHrP(−/−) Mammary Buds Supports a Role for BMP Signaling and MMP2 in the Initiation of Ductal Morphogenesis

Parathyroid hormone-related protein (PTHrP) acts on the mammary mesenchyme and is required for proper embryonic mammary development. In order to understand PTHrP’s effects on mesenchymal cells, we profiled gene expression in WT and PTHrP(−/−) mammary buds, and in WT and K14-PTHrP ventral skin at E15...

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Hauptverfasser: Hens, Julie, Dann, Pamela, Hiremath, Minoti, Pan, Tien-Chi, Chodosh, Lewis, Wysolmerski, John
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862621/
https://ncbi.nlm.nih.gov/pubmed/19795511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.22097
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