Guanine Analogues Enhance Antisense Oligonucleotide-induced Exon Skipping in Dystrophin Gene In Vitro and In Vivo

Exon skipping has demonstrated great potential for treating Duchenne muscular dystrophy (DMD) and other diseases. We have developed a drug-screening system using C2C12 myoblasts expressing a reporter green fluorescent phosphate (GFP), with its reading frame disrupted by the insertion of a targeted d...

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Detalhes bibliográficos
Main Authors: Hu, Yihong, Wu, Bo, Zillmer, Allen, Lu, Peijuan, Benrashid, Ehsan, Wang, Mingxing, Doran, Timothy, Shaban, Mona, Wu, Xiaohua, Long Lu, Qi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862535/
https://ncbi.nlm.nih.gov/pubmed/20087314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.320
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