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Diastereoselective Synthesis of trans-β-Lactams Using a Simple Multifunctional Catalyst

A catalytic, highly diastereoselective process for the synthesis of trans-β-lactams is reported. This system is based on a phosphonium fluoride precatalyst that both activates the nucleophile and directs the reaction process for high yield and diastereoselectivity.

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Detalhes bibliográficos
Main Authors: Abraham, Ciby J., Paull, Daniel H., Dogo-Isonagie, Cajetan, Lectka, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862499/
https://ncbi.nlm.nih.gov/pubmed/20442797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1055/s-0029-1217348
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