A nuclear-mitochondrial DNA interaction affecting hearing impairment in mice

The pathophysiologic pathways and clinical expression of mitochondrial DNA (mtDNA) mutations are not well understood. This is mainly the result of the heteroplasmic nature of most pathogenic mtDNA mutations and of the absence of clinically relevant animal models with mtDNA mutations. mtDNA mutations...

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Bibliografiske detaljer
Main Authors: Johnson, Kenneth R., Zheng, Qing Yin, Bykhovskaya, Yelena, Spirina, Olga, Fischel-Ghodsian, Nathan
Format: Artigo
Sprog:Inglês
Udgivet: 2001
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862214/
https://ncbi.nlm.nih.gov/pubmed/11175788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/84831
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