Mapping Spatial Relationships between Residues in the Ligand-Binding Domain of the 5-Ht(3) Receptor Using a Molecular Ruler

The serotonin 5-HT(3) receptor (5-HT(3)R) is a member of the Cys-loop ligand-gated ion channel family. We used a combination of site-directed mutagenesis, homology modeling, and ligand-docking simulations to analyze antagonist-receptor interactions. Mutation of E236, which is near loop C of the bind...

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Detaylı Bibliyografya
Asıl Yazarlar: Nyce, Heather L., Stober, Spencer T., Abrams, Cameron F., White, Michael M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Biophysical Society 2010
Konular:
Channels and Transporters
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862198/
https://ncbi.nlm.nih.gov/pubmed/20441748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.01.034
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