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Mapping Spatial Relationships between Residues in the Ligand-Binding Domain of the 5-Ht(3) Receptor Using a Molecular Ruler
The serotonin 5-HT(3) receptor (5-HT(3)R) is a member of the Cys-loop ligand-gated ion channel family. We used a combination of site-directed mutagenesis, homology modeling, and ligand-docking simulations to analyze antagonist-receptor interactions. Mutation of E236, which is near loop C of the bind...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2862198/ https://ncbi.nlm.nih.gov/pubmed/20441748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.01.034 |
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