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Kinetics and Reaction Coordinates of the Reassembly of Protein Fragments Via Forward Flux Sampling

We studied the mechanism of the reassembly and folding process of two fragments of a split lattice protein by using forward flux sampling (FFS). Our results confirmed previous thermodynamics and kinetics analyses that suggested that the disruption of the critical core (of an unsplit protein that fol...

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Hauptverfasser: Borrero, Ernesto E., Contreras Martínez, Lydia M., DeLisa, Matthew P., Escobedo, Fernando A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2010
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862158/
https://ncbi.nlm.nih.gov/pubmed/20441755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.12.4329
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