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Kinetics and Reaction Coordinates of the Reassembly of Protein Fragments Via Forward Flux Sampling

We studied the mechanism of the reassembly and folding process of two fragments of a split lattice protein by using forward flux sampling (FFS). Our results confirmed previous thermodynamics and kinetics analyses that suggested that the disruption of the critical core (of an unsplit protein that fol...

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Autors principals: Borrero, Ernesto E., Contreras Martínez, Lydia M., DeLisa, Matthew P., Escobedo, Fernando A.
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862158/
https://ncbi.nlm.nih.gov/pubmed/20441755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.12.4329
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