Pharmacological inhibition of BLT1 diminishes early abdominal aneurysm formation

Leukotriene B(4) (LTB(4)) is a pro-inflammatory lipid mediator generated by the enzymes 5-lipoxygenase (5-LO) and LTA(4)-hydrolase. LTB(4) signals primarily through its G protein-coupled receptor BLT1, which is highly expressed on specific leukocyte subsets. Recent genetic studies in humans as well...

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Detalhes bibliográficos
Main Authors: Kristo, Fjoralba, Hardy, Gregory J., Anderson, Thomas J.T., Sinha, Sumita, Ahluwalia, Neil, Lin, Alexander Y., Passeri, Jonathan, Scherrer-Crosbie, Marielle, Gerszten, Robert E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862127/
https://ncbi.nlm.nih.gov/pubmed/20035940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2009.11.031
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