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Matrix metalloproteinase (MMP)-13 regulates mammary tumor-induced osteolysis by activating MMP9 and TGFβ signaling at the tumor-bone interface

The tropism of breast cancer cells for bone and their tendency to induce an osteolytic phenotype are a result of interactions between breast cancer cells and stromal cells, and are of paramount importance for bone metastasis. However, the underlying molecular mechanisms remain poorly understood. We...

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Autors principals: Nannuru, Kalyan C., Futakuchi, Mitsuru, Varney, Michelle L., Vincent, Thomas M., Marcusson, Eric G., Singh, Rakesh K.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862120/
https://ncbi.nlm.nih.gov/pubmed/20406980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3251
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