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PHD Fingers: Epigenetic Effectors and Potential Drug Targets
The plant homeodomain (PHD) finger is found in many chromatin-remodeling proteins. This small ~65-residue domain functions as an “effector” that binds specific epigenetic marks on histone tails, recruiting transcription factors and nucleosome-associated complexes to chromatin. Mutations in the PHD f...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Pharmacology and Experimental Therapeutics
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2861807/ https://ncbi.nlm.nih.gov/pubmed/20048137 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mi.9.6.7 |
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