Neisseria meningitidis Induces Brain Microvascular Endothelial Cell Detachment from the Matrix and Cleavage of Occludin: A Role for MMP-8

Disruption of the blood-brain barrier (BBB) is a hallmark event in the pathophysiology of bacterial meningitis. Several inflammatory mediators, such as tumor necrosis factor alpha (TNF-α), nitric oxide and matrix metalloproteinases (MMPs), contribute to this disruption. Here we show that infection o...

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Autori principali: Schubert-Unkmeir, Alexandra, Konrad, Christian, Slanina, Heiko, Czapek, Florian, Hebling, Sabrina, Frosch, Matthias
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861698/
https://ncbi.nlm.nih.gov/pubmed/20442866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000874
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