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Polyglutamine Induced Misfolding of Huntingtin Exon1 is Modulated by the Flanking Sequences
Polyglutamine (polyQ) expansion in exon1 (XN1) of the huntingtin protein is linked to Huntington's disease. When the number of glutamines exceeds a threshold of approximately 36–40 repeats, XN1 can readily form amyloid aggregates similar to those associated with disease. Many experiments sugges...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science
2010
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2861695/ https://ncbi.nlm.nih.gov/pubmed/20442863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000772 |
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