Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission

The eIF4E-binding proteins (4E-BPs) repress translation initiation by preventing eIF4F complex formation. Of the three mammalian 4E-BPs, only 4E-BP2 is enriched in the mammalian brain and plays an important role in synaptic plasticity and learning and memory formation. Here we describe asparagine de...

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Hlavní autoři: Bidinosti, Michael, Ran, Israeli, Sanchez-Carbente, Maria R., Martineau, Yvan, Gingras, Anne-Claude, Gkogkas, Christos, Raught, Brian, Bramham, Clive, Sossin, Wayne S., Costa-Mattioli, Mauro, DesGroseillers, Luc, Lacaille, Jean-Claude, Sonenberg, Nahum
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861547/
https://ncbi.nlm.nih.gov/pubmed/20347422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.02.022
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