In vivo and in vitro Trans-Acylation by BryP, the Putative Bryostatin Pathway Acyltransferase Derived from an Uncultured Marine Symbiont

The putative modular polyketide synthase (PKS) that prescribes biosynthesis of the bryostatin natural products from the uncultured bacterial symbiont of the marine bryozoan Bugula neritina possesses a discrete ORF (bryP) that encodes a protein containing tandem acyltransferase (AT) domains upstream...

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Bibliographic Details
Main Authors: Lopanik, Nicole B., Shields, Jennifer A., Buchholz, Tonia J., Rath, Christopher M., Hothersall, Joanne, Haygood, Margo G., Håkansson, Kristina, Thomas, Christopher M., Sherman, David H.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861360/
https://ncbi.nlm.nih.gov/pubmed/19022178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2008.09.013
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