Generation of stable monoclonal antibody-producing BCR(+) human memory B cells by genetic programming

B cell lymphoma (BCL)6 and Bcl-xL are expressed in germinal center (GC) B cells and enable them to endure the proliferative and mutagenic environment of the GC. By introducing these genes into peripheral blood memory B cells and culturing these cells with factors produced by follicular helper T cell...

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Main Authors: Kwakkenbos, Mark J., Diehl, Sean A., Yasuda, Etsuko, Bakker, Arjen Q., van Geelen, Caroline M.M., Lukens, Michaël V., van Bleek, Grada M., Widjojoatmodjo, Myra N., Bogers, Willy M.J.M., Mei, Henrik, Radbruch, Andreas, Scheeren, Ferenc A., Spits, Hergen, Beaumont, Tim
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861345/
https://ncbi.nlm.nih.gov/pubmed/20023635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2071
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