VHL Deletion Impairs Mammary Alveologenesis but Is Not Sufficient for Mammary Tumorigenesis

Overexpression of hypoxia inducible factor-1 (HIF-1)α, which is common in most solid tumors, correlates with poor prognosis and high metastatic risk in breast cancer patients. Because HIF-1α protein stability is tightly controlled by the tumor suppressor von Hippel-Lindau (VHL), deletion of VHL resu...

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Detalhes bibliográficos
Main Authors: Seagroves, Tiffany N., Peacock, Danielle L., Liao, Debbie, Schwab, Luciana P., Krueger, Robin, Handorf, Charles R., Haase, Volker H., Johnson, Randall S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861092/
https://ncbi.nlm.nih.gov/pubmed/20382704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090310
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