Lack of Glycoprotein 130/Signal Transducer and Activator of Transcription 3-Mediated Signaling in Hepatocytes Enhances Chronic Liver Injury and Fibrosis Progression in a Model of Sclerosing Cholangitis

The 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) model leads to chronic cholestatic liver injury and therefore resembles human diseases such as sclerosing cholangitis and forms of metabolic liver diseases. The role of the interleukin-6/glycoprotein 130 (gp130) system in this context is still unde...

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Main Authors: Plum, Werner, Tschaharganeh, Darjus F., Kroy, Daniela C., Corsten, Eva, Erschfeld, Stephanie, Dierssen, Uta, Wasmuth, Hermann, Trautwein, Christian, Streetz, Konrad L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861089/
https://ncbi.nlm.nih.gov/pubmed/20382701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090469
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