Nrf2 Ameliorates DDC-Induced Sclerosing Cholangitis and Biliary Fibrosis and Improves the Regenerative Capacity of the Liver

The Nrf2 pathway protects against oxidative stress and induces regeneration of various tissues. Here, we investigated whether Nrf2 protects from sclerosing cholangitis and biliary fibrosis and simultaneously induces liver regeneration. Diet containing 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Fragoulis, Athanassios, Schenkel, Julia, Herzog, Miriam, Schellenberg, Tim, Jahr, Holger, Pufe, Thomas, Trautwein, Christian, Kensler, Thomas W, Streetz, Konrad L, Wruck, Christoph Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Nrf2 REDUCES FIBROSIS AND ENHANCES REGENERATION IN LIVER
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542338/
https://ncbi.nlm.nih.gov/pubmed/30825315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfz055
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