Subcellular Localization of Activated AKT in Estrogen Receptor- and Progesterone Receptor-Expressing Breast Cancers : Potential Clinical Implications

Activated v-AKT murine thymoma viral oncogene homolog 1 (AKT)/protein kinase B (PKB) kinase (pAKT) is localized to the plasma membrane, cytoplasm, and/or nucleus in 50% of cancers. The clinical importance of pAKT localization and the mechanism(s) controlling this compartmentalization are unknown. In...

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Detalhes bibliográficos
Main Authors: Badve, Sunil, Collins, Nikail R., Bhat-Nakshatri, Poornima, Turbin, Dmitry, Leung, Samuel, Thorat, Mangesh, Dunn, Sandra E., Geistlinger, Tim R., Carroll, Jason S., Brown, Myles, Bose, Shikha, Teitell, Michael A., Nakshatri, Harikrishna
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861080/
https://ncbi.nlm.nih.gov/pubmed/20228224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090477
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