Feasibility and Diagnostic Utility of Antigen-Specific Interferon-γ Responses for Rapid Immunodiagnosis of Tuberculosis Using Induced Sputum

BACKGROUND: The diagnosis of smear-negative or sputum-scarce tuberculosis (TB) is problematic as culture takes several weeks and representative biological samples are difficult to obtain. RD-1 antigen-specific interferon-γ release assays (IGRAs) are sensitive and specific blood-based tests for the d...

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Main Authors: Cashmore, Tamaryn J., Peter, Jonathan G., van Zyl-Smit, Richard N., Semple, Patricia L., Maredza, Alice, Meldau, Richard, Zumla, Alimuddin, Nurse, Barbara, Dheda, Keertan
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861000/
https://ncbi.nlm.nih.gov/pubmed/20442850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010389
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