Impact of correcting the lymphocyte count to improve the sensitivity of TB antigen-specific peripheral blood-based quantitative T cell assays (T-SPOT.(®)TB and QFT-GIT)

BACKGROUND: The standardized blood-based TB antigen-specific T cell assay, T-SPOT.(®)TB, is ~10% more sensitive than QuantiFERON(®)-TB-GIT (QFT-GIT) in detecting presumed latent TB infection (LTBI). Whilst T-SPOT.(®)TB uses a fixed number of lymphocytes per well, QFT-GIT uses a fixed volume of blood...

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Bibliografiske detaljer
Udgivet i:J Thorac Dis
Main Authors: van Zyl-Smit, Richard N., Lehloenya, Rannakoe J., Meldau, Richard, Dheda, Keertan
Format: Artigo
Sprog:Inglês
Udgivet: AME Publishing Company 2016
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4805805/
https://ncbi.nlm.nih.gov/pubmed/27076944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/jtd.2016.02.65
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