FAVL elevation in human tumors disrupts Fanconi anemia pathway signaling and promotes genomic instability and tumor growth

Fanconi anemia (FA) is a rare human genetic disease caused by mutations in any one of 13 known genes that encode proteins functioning in one common signaling pathway, the FA pathway, or in unknown genes. One characteristic of FA is an extremely high incidence of cancer, indicating the importance of...

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Détails bibliographiques
Auteurs principaux: Zhang, Jun, Zhao, Deping, Park, Hwan Ki, Wang, Hong, Dyer, Roy B., Liu, Wanguo, Klee, George G., McNiven, Mark A., Tindall, Donald J., Molina, Julian R., Fei, Peiwen
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2010
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860942/
https://ncbi.nlm.nih.gov/pubmed/20407210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40908
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