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The ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formation

Mutations in polycystin1 (PKD1) account for the majority of autosomal dominant polycystic kidney disease (ADPKD). PKD1 mutations are also associated with vascular aneurysm and abdominal wall hernia, suggesting a role for polycystin1 in extracellular matrix (ECM) integrity. In zebrafish, combined kno...

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Библиографические подробности
Главные авторы: Mangos, Steve, Lam, Pui-ying, Zhao, Angela, Liu, Yan, Mudumana, Sudha, Vasilyev, Aleksandr, Liu, Aiping, Drummond, Iain A.
Формат: Artigo
Язык:Inglês
Опубликовано: The Company of Biologists Limited 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860853/
https://ncbi.nlm.nih.gov/pubmed/20335443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.003194
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