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A Prochelator Activated by β-Secretase Inhibits Aβ Aggregation and Supresses Copper-Induced Reactive Oxygen Species Formation
[Image: see text] The intersection of the amyloid cascade hypothesis and the implication of metal ions in Alzheimer disease progression has sparked an interest in using metal-binding compounds as potential therapeutic agents. In the present work, we describe a prochelator SWH that is enzymatically a...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2860781/ https://ncbi.nlm.nih.gov/pubmed/20297791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja100943r |
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