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In Vivo Simulations of the Intravenous Dynamics of Submicron Particles of pH-Responsive Cationic Hydrogels in Diabetic Patients

A mathematical model describing glucose-dependent pH swelling and insulin release is developed for pH-sensitive cationic hydrogels in which glucose oxidase and catalase have been immobilized and insulin imbibed. Glucose based swelling and insulin release are simulated for intravenously injected part...

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Detalhes bibliográficos
Main Authors: Farmer, Terry G., Edgar, Thomas F., Peppas, Nicholas A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860336/
https://ncbi.nlm.nih.gov/pubmed/20428328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ie070957b
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