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Synthesis of C14,15-Dihydro-C22,25-epi North Unit of Cephalostatin 1 via “Red-Ox” Modifications of Hecogenin Acetate

[Image: see text] C14,15-Dihydro-C22,25-epi north unit of cephalostatin 1 has been synthesized in eleven operations from a commercially available hecogenin acetate via multiple reductions and oxidations. The key transformations include: i) Cr(VI)-catalyzed E-ring opening, ii) C17 hydroxylation, and...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lee, Seongmin, Fuchs, Philip L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859694/
https://ncbi.nlm.nih.gov/pubmed/19055428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol802122p
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