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Metabolites of MDMA induce oxidative stress and contractile dysfunction in adult rat left ventricular myocytes

Repeated administration of MDMA (ecstasy) produces eccentric left ventricular (LV) dilation and diastolic dysfunction. While the mechanism(s) underlying this toxicity are unknown; oxidative stress plays an important role. MDMA is metabolized into redox cycling metabolites that produce superoxide. In...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Shenouda, Sylvia K., Varner, Kurt J., Carvalho, Felix, Lucchesi, Pamela A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859611/
https://ncbi.nlm.nih.gov/pubmed/19333788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12012-009-9034-6
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