Functional Characterization of the Atypical Integral Membrane Lipid Phosphatase PDP1/PPAPDC2 Identifies a Pathway for Interconversion of Isoprenols and Isoprenoid Phosphates in Mammalian Cells

The polyisoprenoid diphosphates farnesyl diphosphate (FPP) and geranylgeranyl diphosphate (GGPP) are intermediates in the synthesis of cholesterol and related sterols by the mevalonate pathway and precursors for the addition of isoprenyl anchors to many membrane proteins. We developed tandem mass sp...

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Главные авторы: Miriyala, Sumitra, Subramanian, Thangaiah, Panchatcharam, Manikandan, Ren, Hongmei, McDermott, Mark I., Sunkara, Manjula, Drennan, Tracy, Smyth, Susan S., Spielmann, H. Peter, Morris, Andrew J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2010
Предметы:
Lipids
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859554/
https://ncbi.nlm.nih.gov/pubmed/20110354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.083931
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