Gα(q)-mediated Activation of GRK2 by Mechanical Stretch in Cardiac Myocytes: THE ROLE OF PROTEIN KINASE C

G protein-coupled receptor kinase-2 (GRK2) is a critical regulator of β-adrenergic receptor (β-AR) signaling and cardiac function. We studied the effects of mechanical stretch, a potent stimulus for cardiac myocyte hypertrophy, on GRK2 activity and β-AR signaling. To eliminate neurohormonal influenc...

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Bibliographic Details
Main Authors: Malhotra, Ricky, D'Souza, Karen M., Staron, Michelle L., Birukov, Konstantin G., Bodi, Ilona, Akhter, Shahab A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859538/
https://ncbi.nlm.nih.gov/pubmed/20194499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.109272
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