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Apoptosis Protection by Mcl-1 and Bcl-2 Modulation of Inositol 1,4,5-Trisphosphate Receptor-dependent Ca(2+) Signaling

Members of the Bcl-2 protein family play a central role in the regulation of apoptosis. An interaction between anti-apoptotic Bcl-x(L) and the endoplasmic reticulum (ER)-localized inositol trisphosphate receptor Ca(2+) release channel (InsP(3)R) enables Bcl-x(L) to be fully efficacious as an anti-ap...

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Autors principals: Eckenrode, Emily F., Yang, Jun, Velmurugan, Gopal V., Foskett, J. Kevin, White, Carl
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859530/
https://ncbi.nlm.nih.gov/pubmed/20189983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.096040
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