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PKC-δ inhibitors sustain self-renewal of mouse embryonic stem cells under hypoxia in vitro
Under hypoxia, mouse embryonic stem cells (mESCs) lose their self-renewal activity and display an early differentiated morphology mediated by the hypoxia-inducible factor-1α (HIF-1α). Previous studies have demonstrated that PKC-δ is activated by hypoxia and increases the protein stability and transc...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Korean Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2859328/ https://ncbi.nlm.nih.gov/pubmed/20177147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3858/emm.2010.42.4.028 |
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