Isoflurane Protects Human Kidney Proximal Tubule Cells against Necrosis via Sphingosine Kinase and Sphingosine-1-Phosphate Generation

BACKGROUND/AIMS: We previously showed that the inhalational anesthetic isoflurane protects against renal ischemia reperfusion injury in part via sphingosine kinase (SK)-mediated synthesis of sphingosine-1-phosphate (S1P). In this study, we tested the hypothesis that isoflurane directly targets renal...

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Detalhes bibliográficos
Main Authors: Kim, Mihwa, Kim, Minjae, Park, Sang Won, Pitson, Stuart M., Lee, H. Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2010
Assuntos:
Original Report: Laboratory Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859229/
https://ncbi.nlm.nih.gov/pubmed/20234131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000298339
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