S-Methadone augments R-methadone induced respiratory depression in the neonatal guinea pig

Methadone is administered as a racemic mixture, although its analgesic and respiratory effects are attributed to R-isomer activity at the mu-opioid receptor (MOP). Recently, we observed a four-fold increase in inspiratory time in three-day old guinea pigs following an injection of racemic methadone....

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Bibliographic Details
Main Authors: Silverman, Daniel A. N., Nettleton, Rosemary T., Spencer, Katherine B., Wallisch, Michael, Olsen, George D.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858643/
https://ncbi.nlm.nih.gov/pubmed/19744579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.resp.2009.09.001
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