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S-Methadone augments R-methadone induced respiratory depression in the neonatal guinea pig
Methadone is administered as a racemic mixture, although its analgesic and respiratory effects are attributed to R-isomer activity at the mu-opioid receptor (MOP). Recently, we observed a four-fold increase in inspiratory time in three-day old guinea pigs following an injection of racemic methadone....
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2858643/ https://ncbi.nlm.nih.gov/pubmed/19744579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.resp.2009.09.001 |
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