Comprehensive mapping of long range interactions reveals folding principles of the human genome

We describe Hi-C, a method that probes the three-dimensional architecture of whole genomes by coupling proximity-based ligation with massively parallel sequencing. We constructed spatial proximity maps of the human genome with Hi-C at a resolution of 1Mb. These maps confirm the presence of chromosom...

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Main Authors: Lieberman-Aiden, Erez, van Berkum, Nynke L., Williams, Louise, Imakaev, Maxim, Ragoczy, Tobias, Telling, Agnes, Amit, Ido, Lajoie, Bryan R., Sabo, Peter J., Dorschner, Michael O., Sandstrom, Richard, Bernstein, Bradley, Bender, M. A., Groudine, Mark, Gnirke, Andreas, Stamatoyannopoulos, John, Mirny, Leonid A., Lander, Eric S., Dekker, Job
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858594/
https://ncbi.nlm.nih.gov/pubmed/19815776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1181369
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