Extreme lymphoproliferative disease and fatal autoimmune thrombocytopenia in FasL and TRAIL double-deficient mice

To delineate the relative roles of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas ligand in lymphocyte biology and lymphoproliferative disease, we generated mice defective in both molecules. B6.GT mice develop severe polyclonal lymphoproliferative disease because of accumula...

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Detalhes bibliográficos
Main Authors: Sedger, Lisa M., Katewa, Arna, Pettersen, Ann K., Osvath, Sarah R., Farrell, Geoff C., Stewart, Graeme J., Bendall, Linda J., Alexander, Stephen I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858490/
https://ncbi.nlm.nih.gov/pubmed/20185587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-11-255497
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