BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells

In a previously developed inducible transgenic mouse model of chronic myeloid leukemia, we now demonstrate that the disease is transplantable using BCR-ABL(+) Lin(−)Sca-1(+)c-kit(+) (LSK) cells. Interestingly, the phenotype is more severe when unfractionated bone marrow cells are transplanted, yet n...

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Hauptverfasser: Schemionek, Mirle, Elling, Christian, Steidl, Ulrich, Bäumer, Nicole, Hamilton, Ashley, Spieker, Tilmann, Göthert, Joachim R., Stehling, Martin, Wagers, Amy, Huettner, Claudia S., Tenen, Daniel G., Tickenbrock, Lara, Berdel, Wolfgang E., Serve, Hubert, Holyoake, Tessa L., Müller-Tidow, Carsten, Koschmieder, Steffen
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2010
Schlagworte:
Plenary Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858483/
https://ncbi.nlm.nih.gov/pubmed/20053753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-04-215376
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