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TSH-Based Protocol, Tablet Instability, and Absorption Effects on L-T(4) Bioequivalence
BACKGROUND: FDA Guidance for pharmacokinetic (PK) testing of levothyroxine (L-T(4)) for interbrand bioequivalence has evolved recently. Concerns remain about efficacy and safety of the current protocol, based on PK analysis following supraphysiological L-T(4) dosing in euthyroid volunteers, and rece...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Mary Ann Liebert, Inc.
2009
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2858298/ https://ncbi.nlm.nih.gov/pubmed/19191742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2008.0148 |
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