Structure of a Virulence Regulatory Factor CvfB Reveals a Novel Winged-helix RNA Binding Module

CvfB is a conserved regulatory protein important for the virulence of Staphylococcus aureus. We show here that CvfB binds RNA. The crystal structure of the CvfB ortholog from Streptococcus pneumoniae at 1.4 Å resolution reveals a unique RNA binding protein that is formed from a concatenation of well...

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Autori principali: Matsumoto, Yasuhiko, Xu, Qingping, Miyazaki, Shinya, Kaito, Chikara, Farr, Carol L., Axelrod, Herbert L., Chiu, Hsiu-Ju, Klock, Heath E., Knuth, Mark W., Miller, Mitchell D., Elsliger, Marc-André, Deacon, Ashley M., Godzik, Adam, Lesley, Scott A., Sekimizu, Kazuhisa, Wilson, Ian A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858061/
https://ncbi.nlm.nih.gov/pubmed/20399190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.02.007
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