An α-galactosylceramide C20:2 N-acyl variant enhances anti-inflammatory and regulatory T cell-independent responses that prevent type 1 diabetes

Protection from type 1 diabetes (T1D), a T helper type 1 (Th1)-mediated disease, is achievable in non-obese diabetic (NOD) mice by treatment with α-galactosylceramide (α-GalCer) glycolipids that stimulate CD1d-restricted invariant natural killer T (iNK T) cells. While we have reported previously tha...

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Detalhes bibliográficos
Main Authors: Ly, D, Tohn, R, Rubin, B, Blumenfeld, H, Besra, G S, Veerapen, N, Porcelli, S A, Delovitch, T L
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
Assuntos:
Translational Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857941/
https://ncbi.nlm.nih.gov/pubmed/20015094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2009.04074.x
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