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Effect of Stalling after Mismatches on the Error Catastrophe in Nonenzymatic Nucleic Acid Replication

[Image: see text] The frequency of errors during genome replication limits the amount of functionally important information that can be passed on from generation to generation. During the origin of life, mutation rates are thought to have been quite high, raising a classic chicken-and-egg paradox: c...

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Autori principali: Rajamani, Sudha, Ichida, Justin K., Antal, Tibor, Treco, Douglas A., Leu, Kevin, Nowak, Martin A., Szostak, Jack W., Chen, Irene A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2010
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857888/
https://ncbi.nlm.nih.gov/pubmed/20359213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja100780p
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