FOXO3a GOVERNS EARLY AND LATE APOPTOTIC ENDOTHELIAL PROGRAMS DURING ELEVATED GLUCOSE THROUGH MITOCHONDRIAL AND CASPASE SIGNALING

Mechanisms that preserve endothelial cell (EC) integrity remain elusive, but are critical for new strategies directed against endocrine disorders such as diabetes mellitus (DM). Here we demonstrate in primary cerebral ECs with a clinically relevant model of elevated D-glucose that Akt1 and the post-...

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Hlavní autoři: Hou, Jinling, Chong, Zhao Zhong, Shang, Yan Chen, Maiese, Kenneth
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857725/
https://ncbi.nlm.nih.gov/pubmed/20211690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2010.02.037
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