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FOXO3a GOVERNS EARLY AND LATE APOPTOTIC ENDOTHELIAL PROGRAMS DURING ELEVATED GLUCOSE THROUGH MITOCHONDRIAL AND CASPASE SIGNALING
Mechanisms that preserve endothelial cell (EC) integrity remain elusive, but are critical for new strategies directed against endocrine disorders such as diabetes mellitus (DM). Here we demonstrate in primary cerebral ECs with a clinically relevant model of elevated D-glucose that Akt1 and the post-...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2857725/ https://ncbi.nlm.nih.gov/pubmed/20211690 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2010.02.037 |
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